Fecal excretion accounts for most of the elimination from the body.
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Biliary excretion or fecal excretion is the process that initiates in the liver and passes through to the gut until the products are finally excreted along with waste products or feces.
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Gemigliptin has balanced elimination between urinary / fecal excretion and hepatic metabolism; therefore, it does not require dose adjustment in patient with moderate to severe RI . This study evaluated the efficacy and safety of gemigliptin in T2DM patients with moderate to severe RI . This randomized, double-blind, parallel group, phase IIIb study ( study identifier : LG-DPCL015, GUARD study; ClinicalTrials . gov registration number : NCT01968044 ) was composed of a 12-week, placebo controlled period, followed by a 40-week, double-blind active controlled extension period ( placebo switched to linagliptin ).
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